ParkinsonCanadaV1, Main, Exploration, bibRecord, 003101

Association of interleukin-1β polymorphisms with idiopathic Parkinson's disease

Identifieur interne : 003101 ( Main/Exploration ); précédent : 003100; suivant : 003102

Association of interleukin-1β polymorphisms with idiopathic Parkinson's disease

Auteurs : Patrick L. Mcgeer [Canada] ; Koji Yasojima [Canada] ; Edith G. Mcgeer [Canada]

Source :

Neuroscience letters [ 0304-3940 ] ; 2002.

RBID : Pascal:02-0444629

Descripteurs français

Pascal (Inist)
- Interleukine 1β, Polymorphisme, Gène, Microglie, Inflammation, Parkinson maladie, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Autopsy, Brain (immunology), Brain (pathology), Gene, Genotype, Human, Humans, Inflammation, Interleukin 1β, Interleukin-1 (genetics), Microglia, Parkinson Disease (genetics), Parkinson Disease (immunology), Parkinson Disease (pathology), Parkinson disease, Polymorphism, Polymorphism, Genetic (immunology).
MESH :
- chemical , genetics : Interleukin-1.
- genetics : Parkinson Disease.
- immunology : Brain, Parkinson Disease, Polymorphism, Genetic.
- pathology : Brain, Parkinson Disease.
- Aged, Aged, 80 and over, Autopsy, Genotype, Humans.

Abstract

Activated microglia surround degenerating substantia nigra neurons in Parkinson's disease (PD). Such microglia produce high levels of interleukin-1β (IL-1β) and interleukin-1α (IL-1α). T and C alleles exist for the IL-1β -511 regulatory region as well as for the IL-1α -889 regulatory region. The T genotypes of both have been reported to increase the risk of Alzheimer's disease (AD) (Arch. Neurol. 58 (2001) 1790). Since the lesions of PD and AD have similar neuroinflammatory characteristics (Neurology 38 (1988) 1285), we genotyped 100 PD and 100 control postmortem brains for the same polymorphisms. We found a significant increase of the IL-1β T genotype in PD cases compared with controls (X² = 9.65, P = 0.0019). A significant increase was not found for the IL-a T genotype (X² = 1.32, P = 0.23), although there was a trend towards more frequent expression of the T allele.

Affiliations:

Canada

Le document en format XML

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<front><div type="abstract" xml:lang="en">Activated microglia surround degenerating substantia nigra neurons in Parkinson's disease (PD). Such microglia produce high levels of interleukin-1β (IL-1β) and interleukin-1α (IL-1α). T and C alleles exist for the IL-1β -511 regulatory region as well as for the IL-1α -889 regulatory region. The T genotypes of both have been reported to increase the risk of Alzheimer's disease (AD) (Arch. Neurol. 58 (2001) 1790). Since the lesions of PD and AD have similar neuroinflammatory characteristics (Neurology 38 (1988) 1285), we genotyped 100 PD and 100 control postmortem brains for the same polymorphisms. We found a significant increase of the IL-1β T genotype in PD cases compared with controls (X<sup>2</sup>
 = 9.65, P = 0.0019). A significant increase was not found for the IL-a T genotype (X<sup>2</sup>
 = 1.32, P = 0.23), although there was a trend towards more frequent expression of the T allele.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

Association of interleukin-1β polymorphisms with idiopathic Parkinson's disease

Association of interleukin-1β polymorphisms with idiopathic Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.